Thermo Fisher Scientific Phospho-STAT4 (Tyr693) Polyclonal Antibody
Phospho-STAT4 (Tyr693) 폴리클로날 항체로, Western blot, IHC, ELISA에 사용 가능. 사람과 쥐 반응성. Rabbit IgG 기반, 액상 형태이며 Affinity Chromatography로 정제됨. IL-12 신호전달 및 STAT4 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around Y693 of human STAT4 (NP_003142.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.97 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914835 |
Product Specific Information
- Positive test controls include: HeLa
- Target localization: Cytoplasm, Nucleus
- Immunogen sequence: KGYVP
Target Information
STAT4 was originally identified using degenerate primers complementary to conserved regions of other STAT proteins. The STAT4 protein shares 52% similarity with STAT1 and 47% with STAT3. Like other STAT family members, it undergoes tyrosine phosphorylation by Jak1 or Jak2, forming homo- and heterodimers. Tyrosine-phosphorylated STAT4 binds to the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity.
STAT4 expression is mainly found in the thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which is critical for IFN-gamma induction and Th1 response development. STAT4-deficient mice show impaired Th1 and enhanced Th2 differentiation. Additionally, IFN-α/β activation of STAT4 is required for IFN-γ production during viral infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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