Thermo Fisher Scientific IL10RA Polyclonal Antibody
IL10RA 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 반응성 확인. WB, IHC, ICC/IF, ELISA에 적용 가능. 고순도 Affinity Chromatography 정제 및 안정적 PBS/glycerol 보관. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:500 | - |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | View 1 publication |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 265–410 of human IL10RA (NP_0015492) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.73 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855263 |
Product Specific Information
Immunogen sequence:
KLPSVLLFKK PSPFIFISQR PSPETQDTIH PLDEEAFLKV SPELKNLDLH GSTDSGFGST KPSLQTEEPQ FLLPDPHPQA DRTLGNREPP VLGDSCSSGS SNSTDSGICL QEPSLSPSTG PTWEQQVGSN SRGQDDSGID LVQNSE
Target Information
The protein encoded by this gene is a receptor for interleukin 10. It is structurally related to interferon receptors and mediates the immunosuppressive signal of interleukin 10, inhibiting synthesis of proinflammatory cytokines. This receptor promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI3-kinase/AKT pathway. Activation leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants—one protein-coding and one non-coding—have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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