Thermo Fisher Scientific Phospho-GluR1 (Ser845) Recombinant Rabbit Monoclonal Antibody (RM296)
Phospho-GluR1 (Ser845)을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 IHC(Paraffin)에 적합합니다. 높은 특이성과 일관된 로트 간 재현성을 제공합니다. PBS/BSA/glycerol 완충액에 보관되며, -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RM296 |
| Immunogen | A phospho-peptide corresponding to human Phospho-Glutamate Receptor 1 (GluR1) (Ser845) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2744990 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the large rabbit immune repertoire
Target Information
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of L-glutamate induces conformational changes that open the cation channel, converting chemical signals to electrical impulses. The receptor then rapidly desensitizes into a transient inactive state with a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8, GluR1 exhibits resensitization characterized by delayed current accumulation during continuous glutamate exposure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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