Thermo Fisher Scientific PTPN22 Polyclonal Antibody
Human PTPN22 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 연구 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 자가면역질환 관련 연구에 유용.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PTPN22. Recombinant protein control fragment (Product #RP-88582) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646124 |
Product Specific Information
- Immunogen sequence:
SEISAKEELV LHPAKSSTSF DFLELNYSFD KNADTTMKWQ TKAFPIVGEP LQKHQSLDLG SLLFEGCSNS KPVNAAGRYF NSKVPITRTK S - Highest antigen sequence identity to the following orthologs:
- Mouse: 57%
- Rat: 59%
Target Information
The protein tyrosine phosphatase PTPN22 (also known as PTP22, LYP, PEP, formerly PTPN8) is a genetic variant associated with increased risk of autoimmune diseases such as type 1 diabetes and rheumatoid arthritis.
The minor allele of a missense SNP in PTPN22 encodes a hematopoietic-specific protein tyrosine phosphatase known as Lyp.
This risk allele is found in approximately 17% of Caucasian individuals in the general population and about 28% of those with rheumatoid arthritis.
It may disrupt the P1 proline-rich motif necessary for interaction with the SH3 domain of CSK (cytoplasmic tyrosine kinase), altering normal T cell activation regulation.
PTPN22 is speculated to act as an effector and/or regulator of CSK in T cells and other hematopoietic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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