Thermo Fisher Scientific HDAC3 Monoclonal Antibody (3A7B5)
HDAC3 단백질을 타깃으로 하는 Mouse IgG1 단일클론 항체로, Human 시료에 반응합니다. Western blot, IHC, ELISA에 적합하며, 약 48.8kDa의 HDAC3를 검출합니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A7B5 |
| Immunogen | Purified recombinant fragment of HDAC3 (aa224–428) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10983812 |
Product Specific Information
MA5-15443 targets HDAC3 in indirect ELISA, IHC, and WB applications and shows reactivity with Human samples.
The immunogen is a purified recombinant fragment of HDAC3 (aa224–428) expressed in E. coli.
MA5-15443 detects HDAC3, which has a predicted molecular weight of approximately 48.8 kDa.
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
HDAC3 belongs to the histone deacetylase/acuc/apha family and has histone deacetylase activity. It represses transcription when tethered to a promoter and may regulate transcription through its interaction with the zinc-finger transcription factor YY1.
HDAC3 can down-regulate p53 function, thereby modulating cell growth and apoptosis. This gene is considered a potential tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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