Thermo Fisher Scientific RON Monoclonal Antibody (1B5A9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1:10,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1B5A9

Immunogen

Purified recombinant fragment of human RON (aa210-320) expressed in E. Coli. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RON,uniProtId:Q04912-1,ncbiNodeId:9606,antigenRange:210-320,antigenLength:1400,antigenImageFileName:MA5-15441_RON_Q04912-1_House_mouse.svg,antigenImageFileNamePDP:MA5-15441_RON_Q04912-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_10984254

Product Specific Information

MA5-15441 targets RON in indirect ELISA, WB applications and shows reactivity with Human samples.

The MA5-15441 immunogen is purified recombinant fragment of human RON (aa210-320) expressed in E. Coli.

MA5-15441 detects RON which has a predicted molecular weight of approximately 152kDa.

Target Information

MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.