Thermo Fisher Scientific Axl Polyclonal Antibody
AXL 수용체 티로신 키나아제에 특이적인 Thermo Fisher Scientific Axl Polyclonal Antibody. Western blot 및 면역침전(IP) 실험에 적합. Rabbit IgG 폴리클로날 항체로 액상 형태, 1 mg/mL 농도. 암 및 면역 연구용으로 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 250 and 300 of human AXL receptor tyrosine kinase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
AXL is a chronic myelogenous leukemia-associated oncogene also linked to colon cancer and melanoma. It encodes a receptor tyrosine kinase that transduces extracellular signals into the cytoplasm by binding growth factors such as GAS6. AXL is involved in cell proliferation and apoptotic cell clearance. Mice lacking TAM receptors exhibit degenerative and autoimmune phenotypes similar to systemic lupus erythematosus.
AXL may act as an entry receptor for filoviruses and is used to identify Siglec 6+/Axl+ dendritic cells. Expression can be upregulated by TLR ligands (e.g., LPS, poly I:C). Soluble AXL is generated by proteolytic cleavage, and elevated plasma levels may indicate inflammation or cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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