
Thermo Fisher Scientific TAB1 Polyclonal Antibody
Human TAB1 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제된 액상 시약이며, 4°C 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 485 and 504 of Human TAK1-binding protein 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which mediates various intracellular signaling pathways, including those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for TAK1 binding and activation, whereas the N-terminal portion acts as a dominant-negative inhibitor of TGF beta. This protein may function as a mediator between TGF beta receptors and TAK1. Additionally, TAB1 can interact with and activate MAPK14/p38alpha, representing an alternative activation pathway that contributes to MAPK14 responses to various stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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