Thermo Fisher Scientific Axl Polyclonal Antibody
Human AXL 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 4°C 보관, 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 250 and 300 of human AXL receptor tyrosine kinase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
AXL is a chronic myelogenous leukemia-associated oncogene linked to colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces extracellular matrix signals into the cytoplasm by binding growth factors such as vitamin K-dependent protein GAS6, promoting cell proliferation.
TAM receptors are involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors exhibit degenerative and autoimmune phenotypes similar to systemic lupus erythematosus.
Axl may also function as an entry receptor for filoviruses and serves as a marker for Siglec 6+/Axl+ human dendritic cells. Expression of Axl can be upregulated by TLR ligands (e.g., LPS, poly I:C). Soluble Axl, generated by proteolytic cleavage, may indicate inflammation and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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