Thermo Fisher Scientific HDAC9 Monoclonal Antibody (OTI6G4), TrueMAB
Human HDAC9 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 최적화됨. TrueMAB 형식의 고순도 항체로 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보존. 연구용으로만 사용 가능하며 HDAC9 관련 전사 조절 연구에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6G4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 181–460 of human HDAC9 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is a critical component of transcriptional regulation, and histone acetylation plays a major role in this process. Acetylation of lysine residues in the amino terminal tail domain of histone causes conformational changes that increase DNA accessibility to transcription factors.
Several mammalian proteins act as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Conversely, histone deacetylation is associated with transcriptional silencing. The histone deacetylases (HDACs) include HDAC1–9. HDAC9 and HDAC9a are two alternatively spliced isoforms; HDAC9a is 132 amino acids shorter than HDAC9 but both retain catalytic activity and repress myocyte enhancer-binding factor 2-mediated transcription. HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta, and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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