Thermo Fisher Scientific PTGS2 Monoclonal Antibody (OTI2F10), TrueMAB
인간 PTGS2(COX2)를 인식하는 단클론 항체로 Western Blot에 적합합니다. E.coli에서 생산된 재조합 단백질(aa 18-260)을 면역원으로 사용했습니다. 액상 형태, 1 mg/mL 농도이며, PBS/1% BSA/50% 글리세롤 버퍼에 0.02% 아지드 포함. -20°C 보관, 동결/해동 반복 피해야 합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 18–260 of human PTGS2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins. The conversion of arachidonate to prostaglandin H2 is a two-step reaction:
- Cyclooxygenase (COX) reaction converting arachidonate to prostaglandin G2 (PGG2)
- Peroxidase reaction reducing PGG2 to prostaglandin H2 (PGH2)
COX2 is constitutively expressed in certain tissues such as endothelium, kidney, and brain, and is up-regulated under pathological conditions including cancer and inflammation. Up-regulation of COX2 is associated with increased cell adhesion, phenotypic changes, resistance to apoptosis, and tumor angiogenesis. In cancer cells, COX2 contributes to prostaglandin E2 (PGE2) production, influencing motility, proliferation, and apoptosis resistance.
COX2 is naturally inhibited by calcitriol (active Vitamin D). Glucocorticoids repress PTGS2 gene activity by interfering with transcription initiation and elongation. COX2 is a target of NSAIDs such as aspirin, which reduce inflammation-related pain and swelling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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