Thermo Fisher Scientific NFkBp65 Polyclonal Antibody
NFkBp65 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 검증 완료. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, 연구용으로 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from epitope -LRRPSDRE- with non-phosphorylation site Ser276 of human NF-kBp65 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Mouse Brain
- Cellular location: Nuclear, cytoplasmic
Target Information
Nuclear factor kB p65 (NF-kB p65) is encoded by the RELA gene on chromosome 11 in humans. Also known as RelA (v-rel avian reticuloendotheliosis viral oncogene homolog A), it belongs to the Rel protein family. NF-kB p65 forms a heterodimer with p50 or p52 subunits of NF-kB, regulating transcription of immune-related genes. TNF-α binding activates IKK, leading to phosphorylation and degradation of IκB, allowing NF-kB to translocate to the nucleus. It plays a key role in transcription of the immunoglobulin κ (kappa) gene in mature B-lymphoid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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