Thermo Fisher Scientific Notch 1 Polyclonal Antibody
Human Notch 1 단백질을 인식하는 Rabbit Polyclonal Antibody로 WB 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제된 액상 항체이며 0.5 mg/mL 농도. 세포막 및 세포질에 위치한 Notch1 검출에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the C-terminus of human Notch 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast carcinoma
- Cellular location: Cell membrane and cytoplasm
Target Information
The notch gene belongs to a family of epidermal growth factor (EGF)-like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region.
Four notch genes have been described in mammals: Notch1, Notch2, Notch3, and Notch4 (Int-3), which are implicated in the differentiation of the nervous system and other structures.
The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1.
Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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