Thermo Fisher Scientific HPV Type 16/18 E6 Monoclonal Antibody (C1P5)
HPV 16/18 E6 단백질을 인식하는 Thermo Fisher의 단클론 항체. Western blot, IHC, IP 등에 적합하며, HPV 관련 암 연구에 유용. 단백질 A로 정제된 액상 항체로 안정적 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:500 | – |
| Immunoprecipitation (IP) | 1:10–1:500 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Virus |
| Published Species | Virus |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C1P5 |
| Immunogen | Gel-purified HPV-18 E6-beta galactosidase fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1017663 |
Target Information
Human Papilloma Virus (HPV) is responsible for the development of type- and tissue-specific papillomas in the oral cavity and larynx. On the skin, papilloma virus can cause various types of warts, and in the ano-genital region, it is associated with condyloma or carcinoma.
HPV types 1, 6, and 11 are usually associated with benign tissue transformations, while HPV types 16, 18, and 31 are linked to the development of carcinomas such as cervical carcinoma. The role of HPV in non-melanocytic skin tumors is under discussion.
Protein E6 acts as a transcriptional transactivator binding double-stranded DNA. It has transforming activity and, with E6-AP ubiquitin-protein ligase, inactivates the human TP53/p53 tumor suppressor protein by targeting it for degradation.
Clinical relevance: Detection of HPV in cervical smears and biopsies.
Uses: Analysis of E6 expression in cell transformation studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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