Thermo Fisher Scientific CCR2 Recombinant Rabbit Monoclonal Antibody (SN707)
CCR2 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체(SN707). 인간 및 마우스 시료에 반응하며 WB, IHC, Flow 분석에 적합. 고순도 Protein A 정제, 액상 형태로 제공되며 안정적인 저장 조건을 갖춤.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:500 | - |
| Flow Cytometry (Flow) | 1:500–1:1,000 | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN707 |
| Immunogen | Synthetic peptide within N-terminal human CCR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898929 |
Target Information
CCR2, a chemokine receptor, regulates monocyte/macrophage trafficking and is upregulated during inflammation. Polymorphisms in CCR2 may be associated with resistance to HIV-1 infection or delayed progression to AIDS. Its ligand, MCP-1, is produced by endothelial cells, smooth muscle cells, and macrophages, mediating monocyte activation and tissue infiltration in inflammatory disorders such as atherosclerosis, rheumatoid arthritis, and tumor infiltration.
Two isoforms are produced by alternative splicing. CCR2 is expressed in multiple tissues including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessels. Increased CCR2 expression has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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