Thermo Fisher Scientific UBE2C Recombinant Rabbit Monoclonal Antibody (SAIC-41A-1)

Applications

Tested Dilution

Publications

Western Blot (WB)

0.3-1 µg/mL

-

Immunocytochemistry (ICC/IF)

1:100

-

Flow Cytometry (Flow)

1:100

-

ELISA (ELISA)

Assay-dependent

-

Mass Spectrometry (MS)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SAIC-41A-1

Immunogen

Peptide GISAFPESDNLFK, derived from the Ubiquitin-conjugating enzyme E2C, conjugated to KLH. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:UBE2C,uniProtId:O00762-1,ncbiNodeId:9606,antigenRange:49-61,antigenLength:179,antigenImageFileName:MA5-47921_UBE2C_O00762-1_Rabbit.svg,antigenImageFileNamePDP:MA5-47921_UBE2C_O00762-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3074365

Product Specific Information

Specificity: Recognises human UBE2C.

Target Information

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating Lys-11-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.