Thermo Fisher Scientific DUSP1 Monoclonal Antibody (4H7)
DUSP1 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 단클론 항체(4H7). Western blot, ELISA, in situ PLA 등에 사용 가능. 인간 시료 반응성. PBS 용액 형태로 제공되며 보존제 없음. -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.3 ng/mL |
| in situ PLA (PLA) | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4H7 |
| Immunogen | DUSP1 (NP_004408, 305–367 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LLQFESQVLA PHCSAEAGSP AMAVLDRGTS TTTVFNFPVS IPVHSTNSAL SYLQSPITTS PSC
Target Information
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative or heat stress and growth factors. It encodes a protein similar to the non-receptor-type protein-tyrosine phosphatase family and shares sequence similarity with a Tyr/Ser-protein phosphatase from vaccinia virus. The bacterially expressed DUSP1 protein exhibits intrinsic phosphatase activity, specifically inactivating MAP kinase by dephosphorylating both phosphothreonine and phosphotyrosine residues. DUSP1 is involved in the cellular response to environmental stress and the negative regulation of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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