Thermo Fisher Scientific DTYMK Monoclonal Antibody (2C2)
DTYMK 단백질을 인식하는 마우스 단클론 항체. Western blot 및 ELISA에 적합하며, 인간 시료에 반응. DNA 합성 경로 연구 및 항암제 기전 분석에 유용. 액상 형태로 제공되며 -20°C에서 보관.
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Applications
- Western Blot (WB): 1:500–1:1,000
- ELISA: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C2 |
| Immunogen | DTYMK (NP_036277, 103 a.a. – approx. 212 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
VAFTGAKENF SLDWCKQPDV GLPKPDLVLF LQLQLADAAK RGAFGHERYE NGAFQERALR CFHQLMKDTT LNWKMVDASK SIEAVHEDIR VLSEDAIRTA TEKPLGELWK
Target Information
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and plays a key role in the metabolism of pyrimidine analog drugs, including 5-Fluorouracil (5-FU), a chemotherapeutic agent used for several solid tumors. The human DTYMK gene was identified through functional complementation of a Saccharomyces cerevisiae cell cycle mutant (cdc8). DTYMK mRNA levels and enzyme activities are regulated by cell cycle and growth pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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