Thermo Fisher Scientific CD115 (c-fms) Monoclonal Antibody (ROS8G11), FITC

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Additional Formats

• Unconjugated (Cat. MA5-28453)
• APC conjugated (Cat. MA5-28451)
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes the porcine homologue of human CSF1R, also known as CSF-1R, M-CSF receptor, CD115 and c-fms.
CSF1R (CD115) is a single pass type 1 transmembrane protein belonging to the type III protein kinase family and is the cell surface receptor for both CSF1 and IL-34.
Evidence from comparative sequence analysis across a range of vertebrate species indicates that CSF1 and IL-34 interact with distinct regions of CSF1R.

Target Information

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias.
Ligand binding activates the receptor kinase through oligomerization and transphosphorylation.
CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases.
Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.
It acts as a cell-surface receptor for CSF1 and IL34, playing an essential role in survival, proliferation, and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes such as macrophages and monocytes.
Promotes release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammatory processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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