Thermo Fisher Scientific ARHGEF7 Polyclonal Antibody
ARHGEF7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. Western blot과 ELISA에 적합하며, 고순도의 Affinity Chromatography 정제 항체입니다. 세포 접합부 및 세포질 내 단백질 분석 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–260 of human ARHGEF7 (NP_001106984.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.48 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804629 |
Product Specific Information
Immunogen sequence:
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKTFDAN DLYQGQNFNK VLSSLVTLNK VTADIGLGSD SVCARPSSHR IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT DNSNNQLVVR AKFNFQQTNE DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE VKASEKPVSP KSGTLKSPPK GFDTTAINKS YYNVVLQNIL ETENEYSKEL QTVLSTYLRP LQTSEKLSSA
Positive Samples: SW620, Jurkat, COS-1, COS-7, MCF7, K-562, Mouse lung, Mouse heart
Cellular Location: Cell junction, Cell projection, Cytoplasm, cell cortex, focal adhesion, lamellipodium, ruffle
Target Information
The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase, and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline-rich PAK sequence. PIX exists as two isoforms, alpha and beta, both highly expressed in heart, muscle, and thymus tissues of human and rat. The alphaPIX isoform acts as a guanine nucleotide exchange factor (GEF) on Rac, mediating lamellipodia formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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