Thermo Fisher Scientific MEK2 Monoclonal Antibody (GT1721)
MEK2 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체 GT1721. Western blot 및 Immunocytochemistry에 사용 가능. 인간 MEK2 중심 영역 재조합 단백질로 면역화. 단백질 G 정제, 액상 형태, 1 mg/mL 농도. 연구용으로만 사용.
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Thermo Fisher Scientific MEK2 Monoclonal Antibody (GT1721)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT1721 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human MEK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787139 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: 293T, A431, HeLa, HepG2.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MAP2K2 (MEK2) is a dual specificity serine/threonine kinase that plays a critical role in mitogen growth factor signal transduction.
Mitogen activated protein kinase 2 (MEK2 or MAPKK2) belongs to a family of tyrosine/threonine protein kinases that activate ERK1/2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop.
MEK1 and MEK2 are activated by dual phosphorylation on serine 218 and 222 in the activation loop of MEK.
Threonine 292 of MEK1 is phosphorylated by ERK2, serving as a negative feedback loop that suppresses MEK1 activation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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