Thermo Fisher Scientific FERMT2 Monoclonal Antibody (OTI25A4), TrueMAB
FERMT2 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체로, WB, IHC, ICC/IF, IP 등 다양한 분석에 사용 가능. 인간 반응성, Mouse IgG2a 형식, 무보존제, 동결건조 형태로 제공되며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | 2 µg/500 µL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI25A4 |
| Immunogen | Full-length human FERMT2 protein expressed in 293T cells transfected with FERMT2 expression vector |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
FERMT2 (Kindlin-2) is a scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, though it activates integrins only weakly on its own. It binds to membranes enriched in phosphoinositides and promotes integrin-mediated cell adhesion and spreading through interaction with integrins and phospholipid membranes.
It is required for focal adhesion assembly and contributes to linking extracellular matrix adhesion sites with the actin cytoskeleton, influencing actin assembly and cell shape modulation. FERMT2 recruits FBLIM1 to focal adhesions and participates in TGFB1 and integrin signaling pathways. It stabilizes active CTNNB1 and regulates transcription mediated by CTNNB1 and TCF7L2/TCF4 in the Wnt signaling pathway. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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