Thermo Fisher Scientific FERMT2 Monoclonal Antibody (OTI25A4), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

FERMT2 (Kindlin-2) is a scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, though it activates integrins only weakly on its own. It binds to membranes enriched in phosphoinositides and promotes integrin-mediated cell adhesion and spreading through interaction with integrins and phospholipid membranes.
It is required for focal adhesion assembly and contributes to linking extracellular matrix adhesion sites with the actin cytoskeleton, influencing actin assembly and cell shape modulation. FERMT2 recruits FBLIM1 to focal adhesions and participates in TGFB1 and integrin signaling pathways. It stabilizes active CTNNB1 and regulates transcription mediated by CTNNB1 and TCF7L2/TCF4 in the Wnt signaling pathway. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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