Thermo Fisher Scientific Lamin A/C Polyclonal Antibody
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Lamin A/C 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트에 반응. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합. 고순도 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공.
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Thermo Fisher Scientific Lamin A/C Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Lamin A/C (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.16 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736077 |
Product Specific Information
- Positive Control: HeLa, A431, NIH-3T3, K562
- Predicted Reactivity: Xenopus laevis (81%), Dog (98%), Pig (98%), Rhesus Monkey (99%), Chimpanzee (100%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Lamins are intermediate filament proteins forming a matrix on the inner surface of the nuclear envelope. Lamins A and C are alternatively spliced forms of the LMNA gene.
Mutations in LMNA are associated with various disorders including:
- Emery-Dreifuss muscular dystrophy
- Dunnigan-type familial partial lipodystrophy (FPLD)
- Limb-girdle muscular dystrophy (LGMD1B)
- Dilated cardiomyopathy (CMD1A)
- Axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1)
- Mandibuloacral dysplasia (MAD)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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