Thermo Fisher Scientific DFNA5 Polyclonal Antibody
DFNA5 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 인간, 생쥐, 랫트 시료에서 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 264–309 of human DFNA5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553830 |
Product Specific Information
- Detects endogenous DFNA5 protein at ~54 kDa.
- Purity: >95% by SDS-PAGE.
Target Information
DFNA5 (Deafness, Autosomal Dominant 5)
Also known as ICERE-1, DFNA5 is a 496 amino acid protein expressed in cochlea, placenta, brain, heart, liver, lung, and pancreas. It exists as two alternatively spliced isoforms (short and long).
Mutations in DFNA5 cause non-syndromic sensorineural deafness (autosomal dominant type 5), a form of hearing loss due to defects in auditory signal processing structures.
The DFNA5 gene is located on human chromosome 7, which contains over 1,000 genes (~5% of the human genome). Gene defects on chromosome 7 are associated with conditions such as Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia, and Shwachman-Diamond syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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