Thermo Fisher Scientific TOLLIP Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 Rabbit Polyclonal 항체로 TOLLIP 단백질 검출에 적합합니다. Western Blot 및 Immunocytochemistry에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS buffer에 0.02% sodium azide 포함, 냉장 또는 냉동 보관 권장.
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Thermo Fisher Scientific TOLLIP Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the center of human TOLLIP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154061 |
Product Specific Information
- Suggested positive control: Rat brain tissue lysate
- PA5-20205 can be used with blocking peptide PEP-0331
Target Information
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the Toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses.
TLRs act through adaptor molecules to activate various kinases and transcription factors, enabling the organism to respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF.
TOLLIP associates directly with TLR2 and TLR4, acting as an inhibitor of TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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