Thermo Fisher Scientific ASK1 Polyclonal Antibody
ASK1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB 및 ICC/IF에 적합합니다. 인간과 마우스 시료에서 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며, 안정적인 액상 형태로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 2 µg/mL
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the carboxy terminus of human ASK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152007 |
Product Specific Information
- A suggested positive control is SW1353 cell lysate.
- PA5-20200 can be used with blocking peptide PEP-0328.
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas and activated in response to various extracellular stimuli, including cytokines, growth factors, and environmental stresses.
ASK1 (Apoptosis Signal-Regulating Kinase 1), also known as MAPKKK5, activates two subgroups of MAPKK—MKK4 and MKK6—which in turn activate JNK and p38 MAP kinases, respectively.
ASK1/MAPKKK5 is activated by TNFR and Fas through interactions with TRAF family members and Daxx. Overexpression of ASK1 induces apoptotic cell death, while catalytically inactive ASK1 inhibits TNF-α-induced apoptosis.
ASK1 is expressed in various human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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