Thermo Fisher Scientific TrkA Polyclonal Antibody
Thermo Fisher Scientific의 TrkA Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 WB, IHC, ELISA에 사용 가능합니다. Rabbit IgG 기반의 비결합 항체로, 고순도 친화 크로마토그래피로 정제되었습니다. 신경세포 발달 및 MAPK 경로 연구에 적합합니다.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–280 of human TrkA (NP_002520.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914358 |
Product Specific Information
Positive test controls include HeLa, K-562, NIH/3T3, Mouse liver, Mouse heart, Rat liver.
The target is usually found in the following locations:
- Cell membrane
- Early endosome membrane
- Late endosome membrane
- Single-pass type I membrane protein
Immunogen sequence:
MLRGGRRGQL GWHSWAAGPG SLLAWLILAS AGAAPCPDAC CPHGSSGLRC TRDGALDSLH HLPGAENLTE LYIENQQHLQ HLELRDLRGL GELRNLTIVK SGLRFVAPDA FHFTPRLSRL NLSFNALESL SWKTVQGLSL QELVLSGNPL HCSCALRWLQ RWEEEGLGGV PEQKLQCHGQ GPLAHMPNAS CGVPTLKVQV PNASVDVGDD VLLRCQVEGR GLEQAGWILT ELEQSATVMK SGGLPSLGLT LANVTSDLNR KNVTCWAEND VGRAEVSVQV
Target Information
NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system.
TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.
The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes.
Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(PA5-120786_TrkA_P04629-1_Rabbit.svg 및 PA5-120786_TrkA_P04629-1_Rabbit_PDP.jpeg)
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