Thermo Fisher Scientific PTCH Polyclonal Antibody
PTCH 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. Human, Mouse, Rat 시료에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to a C-terminal region of the human Patched 1 protein (within residues 1200–1350). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.22 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154551 |
Target Information
This gene encodes a member of the patched gene family. The encoded protein acts as a receptor for sonic hedgehog, a secreted molecule involved in embryonic structure formation and tumorigenesis, as well as for desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, and holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full-length sequences and biological validity are not yet confirmed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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