Thermo Fisher Scientific TEK Polyclonal Antibody
TEK(TIE2) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 1 mg/mL 농도. 혈관 형성 관련 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,500
- Publications: 참조 가능
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200
- Publications: 참조 가능
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to an internal region of the human TIE2 protein (within residues 250–400). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153466 |
Product Specific Information
Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Target Information
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling is critical for endothelial cell–smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations.
Angiopoietin-1 binds to this receptor and mediates a signaling pathway involved in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP.
HSCs expressing TIE2 are quiescent and antiapoptotic, comprising a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-23082_TIE2_TEK_Q02763-1_Rabbit_PDP.jpeg, PA5-23082_TIE2_TEK_Q02763-1_Rabbit.svg)
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