Thermo Fisher Scientific LAMTOR1 Polyclonal Antibody
LAMTOR1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 적합합니다. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 내 콜레스테롤 대사 및 mTORC1 경로 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25–1:100 |
| Immunocytochemistry (ICC/IF) | 1:25–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to a C-terminal region of the human c11orf59 protein (within residues 50–250). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol, 0.1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152073 |
Product Specific Information
The target sequence has 98% sequence homology with bovine.
Target Information
The Ragulator complex is comprised of three proteins — C11orf59, ROBLD3, and MAPKSP1 — which target mTORC1 to lysosomal surfaces. This normal endosomal trafficking is exploited by certain viruses, including coronavirus, which shows increased replication when C11orf59 is interfered with.
C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis.
C11orf59 and PPAR-alpha cooperate to regulate lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion and dysregulation of the normal mTOR pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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