Thermo Fisher Scientific CXCR5/CD185 Polyclonal Antibody
CXCR5/CD185 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P/F), ELISA 등에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관. B세포 이동 및 CXCR5 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CXCR5, amino acids 281–372 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CXCR5 (C-X-Chemokine Receptor Type 5, CD185), also known as Burkitt lymphoma receptor 1 (BLR1), belongs to the CXC chemokine receptor family and functions as a G protein-coupled receptor for chemokine BLC.
CXCR5 is specifically expressed in Burkitt’s lymphoma and lymphoid tissues such as lymph node follicles and spleen. It plays a crucial role in B cell migration. Expression has been observed in human blood, salivary gland, and various animal organs including lymphatic tissues, bone marrow, brain, liver, spleen, and tonsil.
G-protein Coupled Receptors (GPCRs) form one of the largest families of signaling molecules, characterized by seven transmembrane helices. They exist in active and inactive forms and are regulated by diverse ligands and downstream signaling pathways.
Negative regulation of GPCRs is critical for cellular physiology and continues to be a major focus in pharmacological research, leading to the development of drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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