Thermo Fisher Scientific Factor X Monoclonal Antibody (9051)

Applications

Western Blot (WB)

• Tested Dilution: 5 µg/mL

ELISA

• Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

MA1-43036 detects Factor X in mouse samples.
MA1-43036 has been successfully used in Western blot and ELISA applications.
MA1-43036 was derived from mouse Factor X.

Target Information

F10 undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR.
Two chains of the factor are held together by one or more disulfide bonds; the light chain contains two EGF-like domains, while the heavy chain contains the catalytic domain homologous to other hemostatic serine proteases.
The mature factor is activated by cleavage of the activation peptide by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway).
Activated factor X converts prothrombin to thrombin in the presence of factor Va, Ca²⁺, and phospholipid during blood clotting.
Mutations in this gene cause factor X deficiency, a hemorrhagic condition of variable severity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.