Thermo Fisher Scientific Factor VIII Monoclonal Antibody (9035)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-43037 detects Factor VIII in mouse samples.
It has been successfully used in Western blot and ELISA applications.
This antibody was derived from mouse Factor VIII.

Target Information

The Factor VIII gene encodes a coagulation factor that participates in the intrinsic pathway of blood coagulation.
Factor VIII acts as a cofactor for Factor IXa, which, in the presence of Ca²⁺ and phospholipids, converts Factor X to its activated form, Xa.

This gene produces two alternatively spliced transcripts:

• Transcript variant 1 (isoform a): Encodes a large glycoprotein circulating in plasma, associated with von Willebrand factor in a noncovalent complex, and undergoes multiple cleavage events.
• Transcript variant 2 (isoform b): Encodes a smaller protein consisting mainly of the phospholipid-binding domain of Factor VIIIc, essential for coagulant activity.

Defects in this gene cause hemophilia A, a common recessive X-linked coagulation disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.