Thermo Fisher Scientific Angiopoietin 2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Angiopoietin 2. Validated for WB, IHC(P), and ICC/IF. Recommended positive controls include HepG2 and HUVEC. Suitable for research use in angiogenesis and vascular biology studies.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Angiopoietin 2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–308 of Human Angiopoietin 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.44 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544775 |
Product Specific Information
- Recommended positive controls: HepG2, HUVEC, mouse lung
- Predicted reactivity: Mouse (84%), Rat (85%), Dog (90%), Pig (92%), Bovine (89%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ANG-2 binds to the endothelial cell-specific receptor Tie-2 but, unlike ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and can act either as an agonist or antagonist of Tie-2–induced angiogenesis depending on the physiological and biochemical environment.
The signaling interactions of ANG-1, ANG-2, and Tie-2, along with ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels.
Mature human ANG-2 is a secreted protein containing 480 amino acid residues, composed of an alpha-helix-rich coiled coil N-terminal domain and a fibrinogen-like C-terminal domain. ANG-2 exists predominantly as a disulfide-linked dimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.