Thermo Fisher Scientific Tau Polyclonal Antibody
Tau 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 사용 가능. Human 및 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제됨. Alzheimer’s disease 연구 등 신경퇴행성 질환 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 2 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–286 of Human Tau |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.34 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544763 |
Product Specific Information
- Recommended positive controls: SK-N-SH, IMR32, SK-N-AS, mouse brain
- Predicted reactivity: Chimpanzee (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. Its main function is to promote tubulin polymerization and stabilize microtubules.
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that Tau acts as a linker between both structures.
Axonal polarity is determined by TAU/MAPT localization in the neuronal cell body domain defined by the centrosome.
Short isoforms contribute to cytoskeletal plasticity, while longer isoforms aid stabilization.
In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease brains.
Hyper-phosphorylation impairs Tau’s microtubule-binding function, leading to cytoskeletal destabilization and neuronal degeneration.
Tau phosphorylation is mediated by multiple kinases such as GSK-3β, PKA, cdk5, and casein kinase II.
Hyper-phosphorylated Tau is also found in neurofibrillary lesions associated with Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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