Thermo Fisher Scientific Tau Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: SK-N-SH, IMR32, SK-N-AS, mouse brain
• Predicted reactivity: Chimpanzee (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. Its main function is to promote tubulin polymerization and stabilize microtubules.
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that Tau acts as a linker between both structures.
Axonal polarity is determined by TAU/MAPT localization in the neuronal cell body domain defined by the centrosome.
Short isoforms contribute to cytoskeletal plasticity, while longer isoforms aid stabilization.

In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease brains.
Hyper-phosphorylation impairs Tau’s microtubule-binding function, leading to cytoskeletal destabilization and neuronal degeneration.
Tau phosphorylation is mediated by multiple kinases such as GSK-3β, PKA, cdk5, and casein kinase II.
Hyper-phosphorylated Tau is also found in neurofibrillary lesions associated with Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.