Thermo Fisher Scientific NAG-1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Immunogen

This affinity purified antibody was prepared by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminal end of human NAG-1 protein. A residue of cysteine was added to facilitate coupling to KLH.

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

This antibody specifically reacts with an H variant sequence of human NAG-1 protein from human tissues. A BLAST analysis suggests partial reactivity with NAG-1 from chimpanzee and macaque based on a 92% homology. Cross-reactivity with NAG-1 from other sources has not been determined.

Target Information

GDF-15 belongs to the TGF-beta cytokine family, which plays an important role during prenatal development, postnatal growth, and tissue remodeling.
GDF-15 is expressed predominantly in the placenta and, to a lesser extent, in various tissues. Its presence in amniotic fluid and elevated levels in pregnant women’s sera suggest involvement in gestation and embryonic development.
GDF-15 generally exerts tumor suppressive activities and is produced in response to activation of the p53 pathway. Serum levels of GDF-15 correlate positively with neoplastic progression in several cancers, including colorectal, pancreatic, and prostate types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.