Thermo Fisher Scientific Phospho-MER/SKY (Tyr749, Tyr681) Polyclonal Antibody
Phospho-MER/SKY (Tyr749, Tyr681) 폴리클로날 항체로 인간, 마우스, 랫트에 반응합니다. Western blot, IHC, ELISA에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 세포 생존, 이동, 분화 및 식세포 작용 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:100–1:300 | - |
| ELISA | 1:10,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human MerTK/Tyro3 around the phosphorylation site of Y749/681 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608093 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1, or GAS6. It regulates various physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding induces autophosphorylation of MERTK, creating docking sites for downstream signaling molecules such as GRB2 or PLCG2, leading to phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1.
MERTK signaling is involved in macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and retinal pigment epithelium (RPE) function. It also plays a role in inhibiting TLR-mediated innate immune responses by activating STAT1, which induces SOCS1 and SOCS3 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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