Thermo Fisher Scientific PRR5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Positive test controls: 293T, HepG2, SH-SY5Y, Mouse liver, Mouse brain, Rat liver
• Immunogen sequence:
  SRGVTEDYLR LETLVQKVVS PYLGTYGLHS SEGPFTHSCI LEKRLLRRSR SGDVLAKNPV VRSKSYNTPL LNPVQEHEAE GAAAGGTSIR RHSVSEMTSC PEPQGFSDPP GQGPTGTFRS SPAPHSGPCP SRLYPTTQPP EQGLDPTRSS LPRSSPENLV DQILESVDSD SEGIFIDFGR GRGSGMSDLE GSGGRQSVV

Target Information

MARK1 (MAP/microtubule affinity-regulating kinase 1) belongs to the MARK family of serine/threonine kinases.
MARK family protein kinases phosphorylate microtubule-associated proteins and may play a role in cytoskeletal stability.
MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a (Homo sapiens).
EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability, and cancer.
Several cDNA clones have been isolated that encode two isoforms of the human ser/thr protein kinase EMK1 called MARK2.
MARK3 was originally identified as a marker induced by DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas.
MARK4 contains an N-terminal serine/threonine kinase domain, a central ubiquitin-associated domain, and a C-terminal KA1-associated kinase domain.
RT-PCR analysis detects upregulated expression of MARK4 in nearly all clinical hepatocellular carcinoma cells.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.