Thermo Fisher Scientific PD-L1 (CD274) Chimeric Recombinant Rabbit Monoclonal Antibody (XGMHc25.1)
PD-L1 (CD274) 표적화된 재조합 토끼 단클론 항체로, 인간 시료에 반응합니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. HEK293 세포에서 발현된 IgG 항체로, Protein A로 정제됨. 연구용으로만 사용.
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Thermo Fisher Scientific PD-L1 (CD274) Chimeric Recombinant Rabbit Monoclonal Antibody (XGMHc25.1)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | XGMHc25.1 |
| Immunogen | The original antibody was generated by immunizing BALB/c mice with a human B7-H1 fusion protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds human PD-L1.
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described member of the B7 family. PD-L1 interacts with programmed death receptor 1 (PD-1), which negatively regulates T-cell receptor (TCR) signaling. Upon receptor binding, PD-L1 decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be further up-regulated upon IFN-gamma stimulation, suggesting its key role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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