Thermo Fisher Scientific NKG2D Chimeric Recombinant Rabbit Monoclonal Antibody (6E5A7)
NKG2D 단백질의 세포외 에피토프를 인식하는 키메릭 재조합 토끼 단일클론 항체. Western blot, ICC/IF, Flow cytometry, Inhibition assay에 적합. 인간 시료 반응성, HEK293 세포 발현, Protein A 정제, 1 mg/mL 농도, PBS buffer에 ProClin 300 함유.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | 1:1,000 | |
| Flow Cytometry (Flow) | Assay-dependent | |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6E5A7 |
| Immunogen | The original antibody was generated by immunizing BALB/c mice with soluble NKG2-D fragments containing amino acids from 64–462 and 123–462. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognizes and binds the extracellular epitope of NKG2D and blocks the interaction between ligand and receptor.
Target Information
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells regulate specific humoral and cell-mediated immunity and preferentially express several calcium-dependent (C-type) lectins involved in NK cell function.
The NK gene encodes a member of the NKG2 family, characterized by a type II membrane orientation (extracellular C terminus) and a C-type lectin domain.
The NKG2 gene family is located within the NK complex, containing several C-type lectin genes preferentially expressed in NK cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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