Thermo Fisher Scientific SLC6A4 Chimeric Recombinant Rabbit Monoclonal Antibody (8B6)
SLC6A4(Serotonin transporter) 타깃의 키메릭 재조합 토끼 단클론 항체(8B6)로, 인간 시료에 반응합니다. ICC/IF, Flow Cytometry, In vitro assay에 적합하며, HEK293 발현 시스템에서 생산된 IgG kappa 형 항체입니다. Protein A로 정제되어 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
| In vitro Assay (IV) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8B6 |
| Immunogen | 8B6 was produced by immunising SERT KO mice with residues 73–616 of wildtype human SERT. Hybridomas were generated using established protocols. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
The 8B6 Fab binds to extracellular loops 2 and 4 of human SERT, as shown by crystallography.
Target Information
SERT (SLC6A4) is an integral membrane protein that transports serotonin from synaptic spaces into presynaptic neurons. It terminates serotonin action and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants such as amphetamines and cocaine and belongs to the sodium:neurotransmitter symporter family. Promoter polymorphisms may affect serotonin uptake rates and are associated with conditions such as sudden infant death syndrome, aggressive behavior in Alzheimer’s disease, and depression susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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