Thermo Fisher Scientific CD223 (LAG-3) Monoclonal Antibody (3DS223H), PE-Cyanine7, eBioscience
인간 CD223(LAG-3)을 인식하는 3DS223H 단클론 항체로, PE-Cyanine7 형광체가 결합된 제품입니다. Flow Cytometry 분석용으로 최적화되어 있으며, 포름알데히드 고정 시에도 인식 가능합니다. 빛에 민감하므로 암조건에서 보관해야 합니다.
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Thermo Fisher Scientific CD223 (LAG-3) Monoclonal Antibody (3DS223H), PE-Cyanine7, eBioscience
Applications and Tested Dilution
- Application: Flow Cytometry
- Tested Dilution: 5 µL (0.06 µg)/test
- Publications: View 7 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-Cyanine7, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3DS223H |
| Immunogen | hCD223-FC PFA 4% |
| Conjugate | PE-Cyanine7 |
| Excitation / Emission Max | 569 / 780 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573429 |
Available Formats
- Alexa Fluor 647
- Alexa Fluor 660
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV Series (395, 563, 661, 737, 805)
- Brilliant Violet Series (421, 480, 605, 650, 711, 786)
- eFluor 450, eFluor 506
- FITC
- NovaFluor Series (Blue, Red, Yellow variants)
- PE, PE-Cyanine5, PE-eFluor 610
- PerCP-eFluor 710
- Super Bright Series (436, 600, 645, 702, 780)
- Request custom conjugation
Product Specific Information
This 3DS223H monoclonal antibody recognizes human CD223 (Lymphocyte Activation Gene 3, LAG-3), a 70-kDa surface glycoprotein of the Ig superfamily with homology to CD4. LAG-3 binds MHC class II with higher affinity than CD4 and negatively regulates T cell activation and proliferation. It is expressed on activated T cells, regulatory T cells, and NK cells, with CD8+ T cells typically showing higher expression.
- Recognizes formaldehyde-fixed epitope
- Reported application: Flow cytometric analysis
- Tested on stimulated normal human peripheral blood cells at 5 µL (0.06 µg)/test
- Light-sensitive: Protect vial and samples from light
- Fixation: Compatible with IC Fixation Buffer (Product # 00-8222) or 1-step Fix/Lyse Solution (Product # 00-5333)
- Excitation: 488–561 nm; Emission: 775 nm
- Laser Compatibility: Blue, Green, Yellow-Green
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
LAG-3 is a 70-kDa surface glycoprotein of the Ig superfamily, homologous to CD4. It binds MHC class II with higher affinity than CD4 and negatively regulates T cell activation and proliferation. Expressed on activated T cells and NK cells; CD8+ T cells show higher expression. Coexpression with CD49b identifies Type 1 regulatory T cells (Tr1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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