Thermo Fisher Scientific Blood Group Antigen Lewis B Monoclonal Antibody (2-25LE (LWB01))
Lewis B 혈액형 항원을 인식하는 Mouse monoclonal antibody. IHC(P), IHC(PFA), ICC/IF 등 다양한 면역염색에 사용 가능. Human 및 Guinea pig 반응성. Protein A/G 정제, 4°C 보관, 연구용 전용.
- 카탈로그번호
- 2525-MSM1-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Blood Group Antigen Lewis B Monoclonal Antibody (2-25LE (LWB01))
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Guinea pig, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2-25LE (LWB01) |
| Immunogen | Mucin isolated from a human ovarian cyst fluid |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids synthesized by exocrine epithelial cells and circulating in body fluids. These glycosphingolipids are involved in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells, forming the Lewis phenotype.
This gene belongs to the fucosyltransferase family, catalyzing the addition of fucose to precursor polysaccharides in the final step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties integrated in mucous secretions. Alterations in the Lewis antigen system have been associated with gastric carcinoma and related lesions. Abnormal expression of Lewis B antigen has been observed in some non-secretory gastric carcinomas and colorectal cancers.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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