Thermo Fisher Scientific Blood Group Antigen Lewis B Monoclonal Antibody (SPM194)
Lewis B 혈액형 항원을 인식하는 Mouse Monoclonal Antibody (SPM194). 사람 및 기니피그 조직 반응성. IHC 및 ICC/IF에 적합. Protein A/G 정제, PBS 기반 저장액, 4°C 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Immunocytochemistry (ICC/IF)
- 2–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Guinea pig, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM194 |
| Immunogen | Mucin isolated from a human ovarian cyst fluid |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids synthesized by exocrine epithelial cells and circulating in body fluids. These glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells, giving rise to their Lewis phenotype.
This gene belongs to the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the final step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities.
Alterations in the Lewis antigen system have been described in gastric carcinoma and related lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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