Thermo Fisher Scientific PIK3CG Monoclonal Antibody (OTI6C6), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member that generates the second messenger PIP2.
Unlike class IA enzymes which signal downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs.
This enzyme phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring and modulates extracellular signals, including those from E-cadherin-mediated cell-cell adhesion.
It plays a key role in maintaining epithelial integrity and regulating NK cell cytotoxicity.
The gene is located in a commonly deleted segment of chromosome 7 associated with myeloid leukemias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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