Thermo Fisher Scientific RWDD3 Monoclonal Antibody (OTI2A4), TrueMAB
인간 RWDD3 단백질을 인식하는 단클론 항체로, Western blot에 최적화됨. TrueMAB 포맷으로 높은 특이성과 재현성 제공. 동결건조 형태로 안정적이며 재구성 및 결합 실험에 적합. 연구용으로만 사용 가능.
- 카탈로그번호
- CF811762
- 판매단위
- pk
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Thermo Fisher Scientific RWDD3 Monoclonal Antibody (OTI2A4), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution
- 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–267 of human RWDD3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
RWDD3 (RSUME) is a small RWD-containing protein that plays a central role in sumoylation by enhancing SUMO conjugation within immune-inflammatory regulatory networks.
It increases Ikappa-Beta sumoylation and stability, inhibits TNF-α-induced kappaB-LUC reporter activity, and suppresses NF-kappa-Beta activity on inflammatory genes such as IL-8 and Cox-2, potentially favoring anti-inflammatory pathways.
RWDD3 expression is induced under hypoxic conditions and may contribute to vascularization. Both BMP-4 and RWDD3 are potential targets for inhibiting pituitary tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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