Thermo Fisher Scientific mGluR8 Polyclonal Antibody
Rabbit polyclonal antibody against human mGluR8 (GRM8). Validated for WB and ELISA. Recognizes cell membrane multi-pass protein. Supplied as liquid, affinity purified, 2.64 mg/mL in PBS with glycerol. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human GRM8 (NP_000836.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.64 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914415 |
Product Specific Information
- Positive test controls: K-562, 22Rv1, HepG2, HeLa
- Subcellular localization: Cell membrane, Multi-pass membrane protein
Immunogen sequence:
MVCEGKRSAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG LFPVHAKGER GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system, activating both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is essential for normal brain function and is implicated in various neuropathologic conditions.
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors divided into three groups based on sequence homology, signal transduction mechanisms, and pharmacologic properties:
- Group I: GRM1, GRM5 – activate phospholipase C
- Group II: GRM2, GRM3
- Group III: GRM4, GRM6, GRM7, GRM8
Groups II and III are linked to inhibition of the cyclic AMP cascade but differ in agonist selectivity.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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