Thermo Fisher Scientific Leptin Receptor Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive test controls: Rat lung, Rat liver
• Subcellular localization: Cell membrane, Secreted, Single-pass type I membrane protein

Immunogen sequence:
ENNDKKSIYY LGVTSIKKRE SGVLLTDKSR VSCPFPAPCL FTDIRVLQDS CSHFVENNIN LGTSSKKTFA SYMPQFQTCS TQTHKIMENK MCDLTV

Target Information

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily that plays a key role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of OB-R by leptin triggers downstream signaling through the JAK/STAT pathway. Several isoforms of OB-R with different signaling capabilities have been reported. The long form of OB-R is expressed in the choroid plexus and hypothalamus, which are associated with satiety and energy expenditure. Mutations in the OB-R (db) or leptin (ob) genes cause early-onset obesity and metabolic abnormalities such as hyperinsulinemia, insulin resistance, and increased adipose tissue.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.