Thermo Fisher Scientific Leptin Receptor Polyclonal Antibody
Leptin 수용체를 인식하는 Rabbit Polyclonal 항체로, WB, ICC/IF, ELISA에 적합합니다. Human 및 Rat 시료에 반응하며, Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며, -20°C에서 안정적으로 보존 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1070–1165 of human LEPR (NP_0022942) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.76 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914416 |
Product Specific Information
- Positive test controls: Rat lung, Rat liver
- Subcellular localization: Cell membrane, Secreted, Single-pass type I membrane protein
Immunogen sequence:
ENNDKKSIYY LGVTSIKKRE SGVLLTDKSR VSCPFPAPCL FTDIRVLQDS CSHFVENNIN LGTSSKKTFA SYMPQFQTCS TQTHKIMENK MCDLTV
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily that plays a key role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of OB-R by leptin triggers downstream signaling through the JAK/STAT pathway. Several isoforms of OB-R with different signaling capabilities have been reported. The long form of OB-R is expressed in the choroid plexus and hypothalamus, which are associated with satiety and energy expenditure. Mutations in the OB-R (db) or leptin (ob) genes cause early-onset obesity and metabolic abnormalities such as hyperinsulinemia, insulin resistance, and increased adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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