Thermo Fisher Scientific Phospho-PFKFB3 (Ser461) Polyclonal Antibody
PFKFB3 단백질의 Ser461 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응. 고순도 정제 및 안정적인 액상 형태로 연구용 적합.
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Thermo Fisher Scientific Phospho-PFKFB3 (Ser461) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PFKFB3 around the phosphorylation site of Ser461 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899255 |
Product Specific Information
This antibody detects endogenous levels of PFKFB3 only when phosphorylated at Ser461.
Target Information
The protein encoded by this gene belongs to a family of bifunctional proteins involved in both the synthesis and degradation of fructose-2,6-bisphosphate (F2,6BP), a regulatory molecule controlling glycolysis in eukaryotes.
It possesses 6-phosphofructo-2-kinase activity for F2,6BP synthesis and fructose-2,6-biphosphatase activity for F2,6BP degradation.
This protein is essential for cell cycle progression and apoptosis prevention, acting as a regulator of cyclin-dependent kinase 1 and linking glucose metabolism to cell proliferation and survival in tumor cells.
Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-114619_PFKFB3_Q16875-1_Rabbit.svg, PA5-114619_PFKFB3_Q16875-1_Rabbit_PDP.jpeg)
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