Thermo Fisher Scientific Phospho-Paxillin (Ser272) Polyclonal Antibody
Phospho-Paxillin (Ser272) 특이적 검출용 Rabbit Polyclonal Antibody로, 인간·마우스·랫트 시료에 반응. Western blot과 IHC(Paraffin)에 최적화. 세포 부착 관련 신호전달 연구에 적합하며, 고순도 액상 형태로 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human Paxillin around the phosphorylation site of Ser272 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899253 |
Product Specific Information
This antibody detects endogenous levels of Paxillin only when phosphorylated at Ser272.
Target Information
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as Src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of Paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain, independent of the extracellular matrix. Although initially discovered in fibroblasts, Paxillin phosphorylation may also play a role in neurite extension during differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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